Nancy P. Keller

Image of Nancy P. Keller, Professor, Dept. Medical Microbiology & Immunology; Dept. Bacteriology

Research Focus

Fungi are ubiquitious microbes that can both benefit and harm society. Our laboratory focus’s on harmful fungi that grow and secret toxins in the edible portion of food and feed crops. Fungal toxins that are found in crops are called mycotoxins. There are three main classes (called genera) of mycotoxin producing fungi: Aspergillus, Penicillium and Fusarium. Our lab works with all three genera where we try to identify (1) genes/molecules/signals that are important for mycotoxin production by these fungi, (2) genes/molecules/signals that are important for growth and survival of these fungi and (3) interactions of these fungi with other microbes. By characterizing such genes/molecules/signals/interactions, we can then create new strategies to combat these fungi to either prevent them from growing on food and feed crops or lessen their ability to produce mycotoxins on food and feed crops. This work is more important than ever as there are many scientific studies showing that climate change is likely to increase the levels of mycotoxins in our food and feed crops. Other major topics in the lab include mining fungal genomes and ensuing chemistries for potentially useful anti-infectives and pharmaceuticals.

Recent Publications

Gaurav Kumar, Jessica L Allen, Livia D S Oster, Mira Syahfriena Amir Rawa, Enrique A Ramírez, Jin Woo Bok, Patreece H Suen, Bellana E Driscoll, John Salogiannis, Nancy P Keller, Samara L Reck-Peterson 2026. Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus. bioRxiv : the preprint server for biology
Mira Syahfriena Amir Rawa, Benjamin J Haefner, Grant R Nickles, Enrique Aguilar-Ramírez, Nancy P Keller, Justin L Eagan 2026. Genetic Dereplication of Multiple Penicillium expansum Biosynthetic Gene Clusters Reveals Cryptic Penta-Cyclopeptide Production. Journal of natural products
Sung Chul Park, Livia D S Oster, Jacob Golan, Jillian Myers, Anne Pringle, Milton T Drott, Nancy P Keller 2026. Leaderless RiPPs expand the repertoire of fungal secondary metabolites. Proceedings of the National Academy of Sciences of the United States of America
Cristobal Carrera Carriel, Spencer A Halberg-Spencer, Marina Kotvanova, Saptarshi Pyne, Sung Chul Park, Hye-Won Seo, Aidan Schmidt, Dante G Calise, Jean-Michel Ané, Nancy P Keller, Sushmita Roy 2026. A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen. Nucleic acids research
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M Mercado Soto, Nancy P Keller, Berl R Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen-Bing Yin 2026. CsdA-LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Meareg G Amare, Miette K Hennessy, Grant Nickles, Sung Chul Park, Sachin Jain, Neta Shlezinger, Nancy P Keller, Mehdi Kabbage 2025. AnBir1: a conserved fungal inhibitor of apoptosis regulates caspase activity and core processes in Aspergillus nidulans. Fungal genetics and biology : FG & B
Milton T Drott, Yen-Wen Wang, E Anne Hatmaker, Nayanna M Mercado-Soto, J Mitch Elmore, Dianiris Luciano-Rosaro, Jae-Hyuk Yu, Antonis Rokas, John G Gibbons, Anna Huttenlocher, Kunlong Yang, Nancy P Keller 2025. Population-Specific Transcriptomic Shifts Underlie Secondary Metabolic Diversification in Aspergillus flavus and the Domestication of Aspergillus oryzae. bioRxiv : the preprint server for biology
Anna E Lehmann, Enrique Aguilar Ramírez, Nancy P Keller, Joseph Heitman 2025. Whole-chromosome duplications drive antimicrobial resistance in Aspergillus fumigatus. bioRxiv : the preprint server for biology

View all Publications @ PubMed