Nancy P. Keller

Image of Nancy P. Keller, Professor, Dept. Medical Microbiology & Immunology; Dept. Bacteriology

Research Focus

Fungi are ubiquitious microbes that can both benefit and harm society. Our laboratory focus’s on harmful fungi that grow and secret toxins in the edible portion of food and feed crops. Fungal toxins that are found in crops are called mycotoxins. There are three main classes (called genera) of mycotoxin producing fungi: Aspergillus, Penicillium and Fusarium. Our lab works with all three genera where we try to identify (1) genes/molecules/signals that are important for mycotoxin production by these fungi, (2) genes/molecules/signals that are important for growth and survival of these fungi and (3) interactions of these fungi with other microbes. By characterizing such genes/molecules/signals/interactions, we can then create new strategies to combat these fungi to either prevent them from growing on food and feed crops or lessen their ability to produce mycotoxins on food and feed crops. This work is more important than ever as there are many scientific studies showing that climate change is likely to increase the levels of mycotoxins in our food and feed crops. Other major topics in the lab include mining fungal genomes and ensuing chemistries for potentially useful anti-infectives and pharmaceuticals.

Recent Publications

Milton T Drott, Yen-Wen Wang, E Anne Hatmaker, Nayanna M Mercado-Soto, J Mitch Elmore, Dianiris Luciano-Rosaro, Jae-Hyuk Yu, Antonis Rokas, John G Gibbons, Anna Huttenlocher, Kunlong Yang, Nancy P Keller 2026. Population-specific transcriptomic shifts underlie secondary metabolic diversification in Aspergillus flavus Link and the domestication of Aspergillus oryzae (Ahlb.). IMA fungus
Gaurav Kumar, Jessica L Allen, Livia D S Oster, Mira Syahfriena Amir Rawa, Enrique Aguilar-Ramírez, Jin Woo Bok, Patreece H Suen, Bellana E Driscoll, John Salogiannis, Nancy P Keller, Samara L Reck-Peterson 2026. Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus. Current biology : CB
Jacqueline A Spieles, Seth D Greengo, Ashley M Holt, Madison C Barnes, Nancy P Keller, Jeniel E Nett, Christina M Hull 2026. Inhibitors of spore germination act against diverse human fungal pathogens. bioRxiv : the preprint server for biology
Dante G Calise, Madeline L Michaelis, Jin Woo Bok, Zhili Chen, Joshua J Coon, Anna Huttenlocher, Benjamin J Chadwick, Nancy P Keller 2026. The Aspergillus fumigatus C2-Domain Protein SppA is required for septal integrity and alters susceptibility to echinocandins and neutrophil killing during infection. bioRxiv : the preprint server for biology
Roberto Regalado, Mariana Santos Craveiro Silva, Euan Price, Nai-Wen Liang, Caroline M Grunenwald, John-Demian Sauer, David J Beebe, Nancy P Keller 2026. Diverse Bacterial Properties Influence Dispersal Along Fungal Networks. Journal of fungi (Basel, Switzerland)
Nancy P Keller 2026. My journey with fungi: the beauty and complexity of fungal natural products. Genetics
Grant R Nickles, Anna Vaiana, Sung Chul Park, Karen Broz, Harrison P Estes, Theo Llewellyn, Milton T Drott, Nancy P Keller, Garima Singh 2026. Tracing the origins of crmA megasynthase through lichen genomes. Current biology : CB
Anna E Lehmann, Enrique Aguilar Ramírez, Nancy P Keller, Joseph Heitman 2026. Aneuploidy promotes transient stress adaptation and metabolic flexibility in the human fungal pathogen Aspergillus fumigatus. Current biology : CB
Dante G Calise, Madeline L Michaelis, Sung Chul Park, Andrew S Wagner, Nancy P Keller 2026. ZfpA-regulated chitin synthesis in Aspergillus fumigatus hyphae determines fungicidal tip lysis by FksA-targeting antifungals. Antimicrobial agents and chemotherapy
Wei Li, Zili Song, Huan Liu, Huomiao Ran, Wenzhao Wang, Kuan Li, Nancy P Keller, Wen-Bing Yin 2026. ThLaeA functions as a conditional repressor to maintain metabolic homeostasis in Trichoderma hypoxylon. mBio

View all Publications @ PubMed