Fungi are ubiquitious microbes that can both benefit and harm society. Our laboratory focus’s on harmful fungi that grow and secret toxins in the edible portion of food and feed crops. Fungal toxins that are found in crops are called mycotoxins. There are three main classes (called genera) of mycotoxin producing fungi: Aspergillus, Penicillium and Fusarium. Our lab works with all three genera where we try to identify (1) genes/molecules/signals that are important for mycotoxin production by these fungi, (2) genes/molecules/signals that are important for growth and survival of these fungi and (3) interactions of these fungi with other microbes. By characterizing such genes/molecules/signals/interactions, we can then create new strategies to combat these fungi to either prevent them from growing on food and feed crops or lessen their ability to produce mycotoxins on food and feed crops. This work is more important than ever as there are many scientific studies showing that climate change is likely to increase the levels of mycotoxins in our food and feed crops. Other major topics in the lab include mining fungal genomes and ensuing chemistries for potentially useful anti-infectives and pharmaceuticals.
Huali Xie, Jie Hu, Xiulan Zhao, Jianwei Chen, Xiaofeng Yue, Changhao Zhou, Jorge C Navarro-Muñoz, Jun Jiang, Xiaoqian Tang, Fang Zhao, E Anne Hatmaker, Antonis Rokas, Amelia E Barber, Milton T Drott, Nancy P Keller, Qi Zhang, Justin J J van der Hooft, Marnix H Medema, Peiwu Li 2026. Large-scale multi-omics profiling reveals environmental and evolutionary drivers of fungal phylogeographic and metabolic diversity.
Nature communications Gaurav Kumar, Jessica L Allen, Livia D S Oster, Mira Syahfriena Amir Rawa, Enrique A Ramírez, Jin Woo Bok, Patreece H Suen, Bellana E Driscoll, John Salogiannis, Nancy P Keller, Samara L Reck-Peterson 2026. Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus.
bioRxiv : the preprint server for biology Grant R Nickles, Cecelia K Stokes, Deborah L Narh, Kira M T Lynn, Savannah R Fuqua, Corbin Bryan, Brooke M Allen, Christopher P Bivins, Jin Woo Bok, J Stephen Brewer, Sikelela T Buthelezi, Jahiya P R M Clark, Kerri L Coon, Lauren R Corby, Martin P A Coetzee, Claudette Dewing, Tuan A Duong, Mathew A Harris, Nancy P Keller, Katlego Kopotsa, Frances A Lane, Holly L Nichols, Alandie Nieuwoudt, Martin A Nuñez, Miguel E Medina Munoz, Sung Chul Park, Nam Q Pham, Kaetlyn T Ryan, Myriam Solís, Rytas Vilgalys, Jasmine Marea Wallace, Yen-Wen Wang, Brenda D Wingfield, Michael J Wingfield, Travis K Worley, Taylor A Zallek, Mostafa Zamanian, Jason D Hoeksema, Milton T Drott, Anne Pringle 2026. Equipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range.
The New phytologist Cristobal Carrera Carriel, Spencer A Halberg-Spencer, Marina Kotvanova, Saptarshi Pyne, Sung Chul Park, Hye-Won Seo, Aidan Schmidt, Dante G Calise, Jean-Michel Ané, Nancy P Keller, Sushmita Roy 2026. A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen.
Nucleic acids research Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M Mercado Soto, Nancy P Keller, Berl R Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen-Bing Yin 2026. CsdA-LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Milton T Drott, Yen-Wen Wang, E Anne Hatmaker, Nayanna M Mercado-Soto, J Mitch Elmore, Dianiris Luciano-Rosaro, Jae-Hyuk Yu, Antonis Rokas, John G Gibbons, Anna Huttenlocher, Kunlong Yang, Nancy P Keller 2025. Population-Specific Transcriptomic Shifts Underlie Secondary Metabolic Diversification in Aspergillus flavus and the Domestication of Aspergillus oryzae.
bioRxiv : the preprint server for biology View all Publications @ PubMed