| Professor, Department of Bacteriology, UW-Madison
1550 Linden Drive (608) 262-4696 3155 Microbial Sciences Building jyu1@wisc.edu |
https://bact.wisc.edu/people_profile.php?t=rf&p=jyu1
- BS 1986, Seoul National University, Seoul, Korea; Microbiology
- MS 1991, University of Wisconsin–Madison; Food Science
- PhD 1995, University of Wisconsin–Madison; Genetics
- Postdoc 1995–1998, Texas A&M University; Genetics
Fungi and mycotoxins: molecular genetics and genomics of spore formation and mycotoxin biosynthesis in filamentous fungiThe genus
Aspergillus encompasses the most common fungi in our environment. Many
Aspergillus species are beneficial to humans, but they also include serious animal and plant pathogens. Moreover, most (if not all)
Aspergillus species have the ability to produce one or more toxic secondary metabolites called mycotoxins. All Aspergilli produce asexual spores as the main means of dispersion and biosynthesis of certain mycotoxins is intimately related with fungal sporulation. The primary interest of my research program is to understand how fungi coordinate growth, sporulation and toxin biosynthesis employing the model fungus
Aspergillus nidulans. We showed that two antagonistic regulatory pathways govern vegetative growth and sporulation in
A. nidulans. Vegetative growth is primarily mediated by a heterotrimeric G protein, which stimulates fungal growth while inhibiting asexual/sexual sporulation as well as production of the carcinogenic mycotoxin sterigmatocystin. We found that the initiation, progression and completion of sporulation are directed by the balanced activities of multiple positive and negative regulators. We are further investigating the detailed molecular mechanisms regulating these fundamental biological processes via forward/reverse genetics, genomics and biochemical analyses.
- Choi D, Alshannaq AF, Yu JH 2024. Safe and effective degradation of aflatoxins by food-grade culture broth of . PNAS nexus 3((7)):pgae271 PMC7912779
- Choi D, Bedale W, Chetty S, Yu JH 2024. Comprehensive review of clean-label antimicrobials used in dairy products. Comprehensive reviews in food science and food safety 23((1)):e13263
- Chen W, Son Y-E, Cho H-J, Choi D, Park H-S, Yu J-H 2024. Phylogenomics analysis of velvet regulators in the fungal kingdom. Microbiology spectrum 12((2)):e0371723 PMC3965051
- Pan J, Yang X, Hu C, Fu T, Zhang X, Liu Z, Wang Y, Zhang F, He X, Yu J-H 2023. Functional, transcriptomic, and lipidomic studies of the gene encoding a phospholipid methyltransferase in . Microbiology spectrum 12((1)):e0216823 PMC8294855
- Kwon JY, Choi YH, Lee MW, Yu JH, Shin KS 2023. The MYST Family Histone Acetyltransferase SasC Governs Diverse Biological Processes in . Cells 12((22)): PMC133676
- Son Y-E, Yu J-H, Park H-S 2023. The novel spore-specific regulator SscA controls conidiogenesis. mBio 14((5)):e0184023 PMC7142095
- Vig I, BenkÅ‘ Z, Gila BC, Palczert Z, Jakab Á, Nagy F, Miskei M, Lee MK, Yu JH, Pócsi I, Emri T 2023. Functional characterization of genes encoding cadmium pumping P-type ATPases in and . Microbiology spectrum 11((5)):e0028323 PMC8233496
- Jang SY, Son YE, Oh DS, Han KH, Yu JH, Park HS 2023. The Forkhead Gene is Necessary for Proper Development in . Journal of microbiology and biotechnology 33((11)):1420-1427 PMC3008278
- Son YE, Yu JH, Park HS 2023. Regulators of the Asexual Life Cycle of . Cells 12((11)): PMC1214532
- Moon H, Lee MK, Bok I, Bok JW, Keller NP, Yu JH 2023. Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans. Microbiology spectrum 11((2)):e0016623 PMC403769
- View all Publications @ PubMed