 | Professor, Dept. Medical Microbiology & Immunology, UW-Madison
1550 Linden Drive
(608) 262-3161
3303 Microbial Sciences Building
ljknoll@wisc.edu |
https://mmi.wisc.edu/staff/knoll-laura/
- B.A. - 1989; Saint Olaf College; Northfield, MN
- Ph.D. - 1994; Washington University School of Medicine; St. Louis, MO
- Postdoctoral Research- Stanford University; Stanford, CA
Molecular parasitology; Vaccine development for the intracellular parasite
Toxoplasma gondiiOur research centers on studying the host/pathogen interactions of the intracellular parasite
Toxoplasma gondii.
T. gondii is well known for causing encephalitis in immunocompromised patients and is a member of the coccidian family of parasites that include
Plasmodium (causative agent of malaria) and
Cryptosporidium (causative agent of diarrhea). My laboratory
uses the latest technologies, including next generation sequencing and mass spectrometry, to uncover the parasite and host genes that are necessary for the establishment and maintenance of chronic infection in animals
. We then use biochemistry, molecular and cell biology to define the how and why these pathogen and host genes are important.
- James R Alvin, Carlos J Ramírez-Flores, Caitlin A Mendina, Anjon Audhya, Laura J Knoll, Molly M Lettman 2025. Toxoplasmosis accelerates the progression of hereditary spastic paraplegia. mSphere
- Rodrigo A Montoro, Michael Moran, Katherine A Overmyer, Andrew Periaccante, Joshua J Coon, Swapnil Lanjewar, Laura J Knoll, Rob Striker 2025. Fatal toxoplasmic encephalitis triggered by anti-TNF therapy. Heliyon PMC11830312
- Carlos J Ramírez-Flores, Nicole D Hryckowian, Andrew N Gale, Kehinde Adebayo Babatunde, Marcos Lares, David J Beebe, Sheena C Kerr, Laura J Knoll 2025. Modeling Toxoplasma gondii-gut early interactions using a human microphysiological system. PLoS neglected tropical diseases
- Laura M Alexander, Saima Khalid, Gina M Gallego-Lopez, Theresa J Astmann, Jee-Hwan Oh, Mark Heggen, Phil Huss, Renee Fisher, Amitava Mukherjee, Srivatsan Raman, In Young Choi, Morgan N Smith, Claude J Rogers, Michael W Epperly, Laura J Knoll, Joel S Greenberger, Jan-Peter van Pijkeren 2024. Development of a Limosilactobacillus reuteri therapeutic delivery platform with reduced colonization potential. Applied and environmental microbiology PMC11577788
- Nicole D Hryckowian, Carlos J Ramírez-Flores, Caitlin Zinda, Sung Chul Park, Martin T Kelty, Laura J Knoll 2024. Host cell-specific metabolism of linoleic acid controls Toxoplasma gondii growth in cell culture. Infection and immunity PMC11475615
- Gina M Gallego-López, Emmanuel Contreras Guzman, Danielle E Desa, Laura J Knoll, Melissa C Skala 2024. Metabolic changes in Toxoplasma gondii-infected host cells measured by autofluorescence imaging. mBio PMC11323734
- Nicole D Hryckowian, Caitlin Zinda, Sung Chul Park, Martin T Kelty, Laura J Knoll 2024. Host cell-specific metabolism of linoleic acid controls Toxoplasma gondii growth in cell culture. bioRxiv : the preprint server for biology PMC10983968
- Nicole D Hryckowian, Laura J Knoll 2024. Sex in a dish: high-efficiency Toxoplasma pre-sexual development. Trends in parasitology PMC10939770
- Steven V John, Gretchen L Seim, Billy J Erazo-Flores, John Steill, Jack Freeman, James A Votava, Nicholas L Arp, Xin Qing, Ron Stewart, Laura J Knoll, Jing Fan 2024. Macrophages undergo functionally significant reprograming of nucleotide metabolism upon classical activation. bioRxiv : the preprint server for biology PMC10793465
- Leah A Owens, Sagan Friant, Bruno Martorelli Di Genova, Laura J Knoll, Monica Contreras, Oscar Noya-Alarcon, Maria G Dominguez-Bello, Tony L Goldberg 2024. VESPA: an optimized protocol for accurate metabarcoding-based characterization of vertebrate eukaryotic endosymbiont and parasite assemblages. Nature communications PMC10776621
- View all Publications @ PubMed
