 | Professor, Department of Bacteriology, UW-Madison
1550 Linden Drive
(608) 262-4696
3155 Microbial Sciences Building
jyu1@wisc.edu |
https://bact.wisc.edu/people_profile.php?t=rf&p=jyu1
- BS 1986, Seoul National University, Seoul, Korea; Microbiology
- MS 1991, University of Wisconsin–Madison; Food Science
- PhD 1995, University of Wisconsin–Madison; Genetics
- Postdoc 1995–1998, Texas A&M University; Genetics
Fungi and mycotoxins: molecular genetics and genomics of spore formation and mycotoxin biosynthesis in filamentous fungiThe genus
Aspergillus encompasses the most common fungi in our environment. Many
Aspergillus species are beneficial to humans, but they also include serious animal and plant pathogens. Moreover, most (if not all)
Aspergillus species have the ability to produce one or more toxic secondary metabolites called mycotoxins. All Aspergilli produce asexual spores as the main means of dispersion and biosynthesis of certain mycotoxins is intimately related with fungal sporulation. The primary interest of my research program is to understand how fungi coordinate growth, sporulation and toxin biosynthesis employing the model fungus
Aspergillus nidulans. We showed that two antagonistic regulatory pathways govern vegetative growth and sporulation in
A. nidulans. Vegetative growth is primarily mediated by a heterotrimeric G protein, which stimulates fungal growth while inhibiting asexual/sexual sporulation as well as production of the carcinogenic mycotoxin sterigmatocystin. We found that the initiation, progression and completion of sporulation are directed by the balanced activities of multiple positive and negative regulators. We are further investigating the detailed molecular mechanisms regulating these fundamental biological processes via forward/reverse genetics, genomics and biochemical analyses.
- Maryam Ajmal, Aneela Nijabat, Iqra Sajjad, Syda Zahra Haider, Wendy Bedale, Jae-Hyuk Yu, Muhammad Anwer Shah, Celestin Ukozehasi, Maha Abdullah Alwaili, Amr Elkelish 2025. Evaluation of basil essential oils for antifungal and anti-aflatoxigenic activity against Aspergillus flavus. Scientific reports PMC11842856
- Zepeng Tu, Dasol Choi, Yuxing Chen, Jae-Hyuk Yu, TuAnh N Huynh 2025. The food fermentation fungus Aspergillus oryzae is a source of natural antimicrobials against Listeria monocytogenes. Journal of dairy science
- Hye-Min Park, Ye-Eun Son, He-Jin Cho, Jae-Hyuk Yu, Hee-Soo Park 2025. Characterization of Blue Light Receptors LreA and LreB in Aspergillus flavus. Journal of microbiology and biotechnology PMC11876014
- Dasol Choi, Ahmad F Alshannaq, Yohan Bok, Jae-Hyuk Yu 2024. Broad-spectrum antimicrobial activities of a food fermentate of Aspergillus oryzae. Microbiology spectrum PMC11619415
- Christopher P Mattison, Rebecca A Dupre, Kristen Clermont, John G Gibbons, Jae-Hyuk Yu 2024. Proteomic characterization of peanut flour fermented by Rhizopus oryzae. Heliyon PMC11320294
- Dasol Choi, Ahmad F Alshannaq, Jae-Hyuk Yu 2024. Safe and effective degradation of aflatoxins by food-grade culture broth of Aspergillus oryzae. PNAS nexus PMC11249075
- Dasol Choi, Wendy Bedale, Suraj Chetty, Jae-Hyuk Yu 2024. Comprehensive review of clean-label antimicrobials used in dairy products. Comprehensive reviews in food science and food safety
- Wanping Chen, Ye-Eun Son, He-Jin Cho, Dasol Choi, Hee-Soo Park, Jae-Hyuk Yu 2024. Phylogenomics analysis of velvet regulators in the fungal kingdom. Microbiology spectrum PMC10845976
- Jiao Pan, Xinyu Yang, Cuiting Hu, Tongtong Fu, Xiuyan Zhang, Zijun Liu, Yu Wang, Fengyu Zhang, Xiaoyuan He, Jae-Hyuk Yu 2023. Functional, transcriptomic, and lipidomic studies of the choC gene encoding a phospholipid methyltransferase in Aspergillus fumigatus. Microbiology spectrum PMC10783049
- Jae-Yoon Kwon, Young-Ho Choi, Min-Woo Lee, Jae-Hyuk Yu, Kwang-Soo Shin 2023. The MYST Family Histone Acetyltransferase SasC Governs Diverse Biological Processes in Aspergillus fumigatus. Cells PMC10670148
- View all Publications @ PubMed
