Charles Czuprynski
- Professor Emeritus, Pathobiological SciencesSchool of Veterinary Medicine
- 1550 Linden Drive
- charles.czuprynski@wisc.edu
- Department Website
Research Focus
The primary interest of our laboratory is studying mechanisms of resistance to bacterial infection. Under this broad heading major projects include: 1) Host, bacterial and environmental factors that influence the pathogenesis of gastrointestinal listeriosis and salmonellosis; 2) Immunotoxicology – adverse effects of polycyclic aromatic hydrocarbons on bone marrow cells and hematopoiesis; 3) Bovine respiratory disease - focus on the effects of Mannheimia haemolytica and its leukotoxin on the activities of bovine leukocytes and lung cells; 4) Histophilus somni – adverse effects on bovine endothelial cells as it relates to vasculitis.
Recent Publications
Anna Marie Hugon, Courtney L Deblois, Heather A Simmons, Andres Mejia, Michele L Schotzo, Charles J Czuprynski, Garret Suen, Thaddeus G Golos 2023. Listeria monocytogenes infection in pregnant macaques alters the maternal gut microbiome†. Biology of reproduction
Hannah Pilch, Nicole Aulik, Donald Sockett, Charles J Czuprynski 2023. Survival of bovine-associated serotypes of Salmonella enterica in bedding sand. JDS communications
Korbin H J West, Curran G Gahan, Patricia R Kierski, Diego F Calderon, Ke Zhao, Charles J Czuprynski, Jonathan F McAnulty, David M Lynn, Helen E Blackwell 2022. Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo. Angewandte Chemie (International ed. in English)
José J Rivera Rivas, Charles J Czuprynski 2021. Histophilus somni stimulates bovine monocyte-derived macrophages to release microparticles that increase fibrin clot formation in vitro. Veterinary microbiology
Hannah E Pilch, Andrew J Steinberger, Donald C Sockett, Nicole Aulik, Garret Suen, Charles J Czuprynski 2021. Assessing the microbiota of recycled bedding sand on a Wisconsin dairy farm. Journal of animal science and biotechnology
Bryce Wolfe, Andrea R Kerr, Andres Mejia, Heather A Simmons, Charles J Czuprynski, Thaddeus G Golos 2019. Sequelae of Fetal Infection in a Non-human Primate Model of Listeriosis. Frontiers in microbiology
José J Rivera Rivas, Charles J Czuprynski 2019. Procoagulant activity of bovine neutrophils incubated with conditioned media or extracellular vesicles from Histophilus somni stimulated bovine brain endothelial cells. Veterinary immunology and immunopathology
Kenneth S Brandenburg, Diego F Calderon, Patricia R Kierski, Charles J Czuprynski, Jonathan F McAnulty 2018. Novel murine model for delayed wound healing using a biological wound dressing with Pseudomonas aeruginosa biofilms. Microbial pathogenesis
Ismail Boukahil, Charles J Czuprynski 2018. Mutual antagonism between Mannheimia haemolytica and Pasteurella multocida when forming a biofilm on bovine bronchial epithelial cells in vitro. Veterinary microbiology
Bryce Wolfe, Gregory J Wiepz, Michele Schotzko, Gennadiy I Bondarenko, Maureen Durning, Heather A Simmons, Andres Mejia, Nancy G Faith, Emmanuel Sampene, Marulasiddappa Suresh, Sophia Kathariou, Charles J Czuprynski, Thaddeus G Golos 2017. Acute Fetal Demise with First Trimester Maternal Infection Resulting from Listeria monocytogenes in a Nonhuman Primate Model. mBio