Nancy P. Keller Home

Personnel at the Food Research Institute, UW–Madison

	Nancy P. Keller
	Core Executive Committee, Food Research Institute Professor, Department of Medical Microbiology & Toxicology; Department of Bacteriology mailing address: 3476 Microbial Sciences, 1550 Linden Drive, University of Wisconsin–Madison Madison, WI 53706–1521
	telephone: 608-262-9795 email: npkeller@wisc.edu

Research Focus	Education	Selected Publications	return to:
Current Research Projects	Program Affiliations	Outreach / Recent Presentations	FRI home page \| FRI Personnel

RESEARCH FOCUS		EDUCATION
Antifungals Fungal molecular biology Mycotoxins Fungal genomics		BS 1977, Penn State University MS 1985, Cornell University PhD 1990, Cornell University Postdoc 1989–1991, USDA, New Orleans, Lousiana

CURRENT RESEARCH PROJECTS		PROGRAM AFFILIATIONS
Mycotoxin reduction. Virulence factors aspergillosis. Virulence factors Aspergillus and Fusarium plant pathogens. Anti-microbial discovery: search for novel fungal metabolites with activity towards food contaminating microbes.		University of Wisconsin–Madison Faculty: Food Pathogens and Toxins Cluster University of Wisconsin–Madison Dept. Plant Pathology; UW–Madison Molecular and Environmental Toxicology Center; UW–Madison Dept. Genetics American Society for Microbiology; Institute of Food Technologists (Professional Member)

SELECTED PUBLICATIONS

Bayram, O., S. Krappmann, M. Ni, J.-W. Bok, K. Helmstaedt, O. Valerius, S. Braus-Stromeyer, N. J. Kwon, N. P. Keller, J.-H. Yu, and G. H. Braus. VelB/VeA/LaeA coordinate light information, fungal development and secondary metabolism. Science 320:1504–1506 (2008).
Brodhagen, M., D. I.Tsitsigiannis, E. Hornung, C. Goebel, I. Feussner, and N. P. Keller. Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem. Molec. Microbiol. 67(2):378–391 (2008).
Dagenais, T., D. Chung, S. Giles, C. Hull, D. Andes, and N. P. Keller. Defects in conidiophore development and conidium-macrophage interactions in a dioxygenase mutant of Aspergillus fumigatus. Infect. Immun. 76:3214–3220 (2008).
Fox, E. M., D. M. Gardiner, N. P. Keller, and B. J. Howlett. A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans. Fungal Genetics Biology 45:671–682 (2008).
Hammond, T. M., M. D. Andrewski, M. Roossinck, and N. P. Keller. Aspergillus mycoviruses are targets and suppressors of RNA silencing. Euk. Cell 2007 7:350–357 (2008).
Hammond, T. M., J.-W. Bok, M. D. Andrewski, Y. Reyes-Domínguez, C. Scazzocchio, and N. P. Keller. RNA silencing gene truncation in the filamentous fungus Aspergillus nidulans. Euk. Cell 7:339–349 (2008).
Maggio-Hall, L., P. Lyne, J. Wolff, and N. P. Keller. A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans. Fungal Genetics Biology 45:180–189 (2008).
Bouhired, S., M. Weber, A. Kempf-Sontag, N. P. Keller, and D. Hoffmeister. Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genetics Biol. 44(11):1134–1145 (2007).
Fedorova, N. D., J. W. Bok, R. A. Cramer, J. R. Wortman, H. S. Kim, W. C. Nierman, and N. P. Keller. Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA. PLO Pathogens 3(4):508–517 (2007).
Garscha, U., F. Jerneren, D. Chung, N. P. Keller, M, Hamberg, and E. H. Oliw. Identification of dioxygenases required for aspergillus development—Studies of products, stereochemistry, and the reaction mechanism. J. Biol. Chem. 282(48):34707–34718 (2007).
Hammond, T. M., D. I. Tsitsigiannis, and N. P. Keller. Development of an Arabidopsis thaliana-based bioassay for investigating seed colonization by mycotoxigenic Aspergillus species. Plant Pathol. 56(5):848–854 (2007).
Hoffmeister, D., and N. P. Keller. Natural products of filamentous fungi: enzymes, genes, and their regulation. Natural Prod. Reports 24(2):393–416 (2007).
Rohlfs, M., M. Albert, N. P. Keller, and F. Kempken. Secondary chemicals protect mould from fungivory. Biol. Lett. 3(5):523–525 (2007).
Shwab, E. K., J. W. Bok, M. Tribus, J. Galehr, S. Graessle, and N. P. Keller. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryotic Cell 6(9):1656–1664 (2007).
Tsitsigiannis, D. I., and N. P. Keller. Oxylipins as developmental and host-fungal communication signals. Trends Microbiol. 15(3)109–118 (2007).
Bok, J. W., D. Chung, S. A. Balajee, K. A. Marr, D. Andes, K. F. Nielsen, J. C. Frisvad, K. A. Kirby, and N. P. Keller. GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Infect. Immun. 74: 6761–6768 (2006).
Bok, J.-W., D. Hoffmeister, L. Maggio-Hall, R. Murillo, J. Glasner, and N. P. Keller. Genomic mining for Aspergillus natural products. Chemistry & Biology 13:31–37 (2006).
Bok, J.-W., D. Noordermeer, S. Kale, and N. P. Keller. Metabolic gene cluster silencing in Aspergillus nidulans. Mol. Microbiol. 61:1636–1645 (2006).
Brodhagen, M., and N. P. Keller. Signaling pathways connecting mycotoxin production and sporulation. Molecular Plant Pathology 7:285–301 (2006).
Keller, N. P. Aspergillus nidulans: A model for elucidation of Aspergillus fumigatus secondary metabolism. In: J. Heitman (ed.), Chapter 17, Molecular Principles of Fungal Pathogenesis, ASM Press (2006).
Keller, N., J. Bok, D. Chung, R. M. Perrin, and E. Keats Shwab. LaeA, a global regulator of Aspergillus toxins. Med. Mycol. 44 Suppl:83–85 (2006).
Tsitsigiannis, D. I., and N. P. Keller. Oxylipins act as determinants of natural product biosynthesis and seed colonization in Aspergillus nidulans. Mol. Microbiol. 59:882-892 (2006).
Bok, J. W., S. A. Balajee, K. A. Marr, D. Andes, K. F. Nielsen, J. C. Frisvad, and N. P. Keller. LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryotic Cell 4(9):1574–1582 (2005).
Hammond, T. M., and N. P. Keller. RNA silencing in Aspergillus nidulans independent of RNA-dependent RNA polymerases. Genetics 169(2):607–617 (2005).
Keller, N. P., G. Turner, and J. W. Bennett. Fungal secondary metabolism: from biochemistry to genomics. Nature Reviews Microbiology 3:937-947 (2005).
Maggio-Hall, L. A., R. A. Wilson, and N. P. Keller. Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta. Molec. Plant Microbe Interactions 18(8):783–793 (2005).
McDonald, T., D. Brown, N. P. Keller, and T. M. Hammond. RNA silencing of mycotoxin production in Aspergillus and Fusarium species. Mol. Plant Microbe Interact. 18(6):539–545 (2005).
Nierman, W. C., A. Pain, M. J. Anderson, J. R. Wortman, H. S. Kim, J. Arroyo, M. Berriman, K. Abe, D. B. Archer, C. Bermejo, J. Bennett, P. Bowyer, D. Chen, M. Collins, R. Coulsen, R. Davies, P. S. Dyer, M. Farman, N. Fedorova, N. Fedorova, T. V. Feldblyum, R. Fischer, N. Fosker, A. Fraser, J. L. Garcia, M. J. Garcia, A. Goble, G. H. Goldman, K. Gomi, S. Griffith-Jones, R. Gwilliam, B. Haas, H. Haas, D. Harris, H. Horiuchi, J. Huang. S. Humphray, J. Jimenez, N. Keller, H. Khouri, K. Kitamoto, T. Kobayashi, S. Konzack, R. Kulkarni, T. Kumagai, A. Lafton, J. P. Latge, W. X. Li, A. Lord, C. Lu, W. H. Majoros, G. S. May, B. L. Miller, Y. Mohamoud, M. Molina, M. Monod, I. Mouyna, S. Mulligan, L. Murphy, S. O’Neil. I. Paulsen, M. A. Peñalva, M. Pertea, C. Price, B. L. Pritchard, M. A. Quail, E. Rabbinowitsch, N. Rawlins, M. A. Rajandream, U. Reichard, H. Renauld, G. D. Robson, S. R. de Córdoba, J. M. Rodriguez-Peña, C. M. Ronning, S. Rutter, S. L. Salzberg, M. Sanchez, J. C. Sánchez-Ferrero, D. Saunders, K, Seeger, R. Squares, S. Squares, M. Takeuchi, F. Tekaia, G. Turner, C. R. V. de Aldana, J. Weidman, O. White, J. Woodward, J. H. Yu, C. Fraser, J. E. Galagan, K. Asai, M. Machida, N. Hall, B. Barrell, and D. W. Denning. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438(7071):1151–1156 (2005).
Tsitsigiannis, D. I., T. M. Kowieski, R. Zarnowski, and N. P. Keller. Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans. Microbiology 151:1809–1821 (2005).
Tsitsigiannis, D. I., J. W. Bok, D. Andes, K. F. Nielsen, J. C. Frisvad, and N. P. Keller. Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect. Immun. 73(8):4548–4559 (2005).
Tsitsigiannis, D. I., S. Kunze, D. K. Willis, L. Feussner, and N. P. Keller. Aspergillus infection inhibits the expression of peanut 13S-HPODE-forming seed lipoxygenases. Molec. Plant Microbe Interactions 18(10):1081–1089 (2005).
Yu, J.-H., and N. P. Keller. Regulation of secondary metabolism in filamentous fungi. Ann. Rev. Phytopathol. 43:437–458 (2005).
Bok, J.-W., and N. P. Keller. LaeA, a regulator of secondary metabolism in Aspergillus. Euk. Cell. 3:527–535 (2004).
Calvo, A. M., J.-W. Bok, W. Brook, and N. P. Keller. ApveA genetically links toxin and sclerotial production in
Aspergillus parasiticus. Appl. Environ. Microbiol. 70:4733–4739 (2004).
Chang, P. K., R. A. Wilson, N. P. Keller, and T. E. Cleveland. Deletion of the Delta 12_oleic acid desaturase gene of a nonaflatoxigenic Aspergillus parasiticus field isolate affects conidiation and sclerotial development. J. Appl. Microbiol. 97(6):1178–1184 (2004).

OUTREACH / SELECTED RECENT PRESENTATIONS

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