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UW-Madison Food Research Institute
Pictures of NPK Nancy P. Keller

Core Executive Committee, Food Research Institute
Professor, Department of Medical Microbiology & Toxicology; Department of Bacteriology, UW-Madison
Faculty: Food Pathogens and Toxins Cluster

3476 Microbial Sciences Building
1550 Linden Drive
(608) 262-9795
npkeller@wisc.edu

Research Interests
Antifungals; Fungal molecular biology; Mycotoxins; Fungal genomics
Department Webpage
http://medmicro.wisc.edu/people_faculty_profile.php?id=npkeller&view=intro
Education
  • BS 1977, Penn State University
  • MS 1985, Cornell University
  • PhD 1990, Cornell University
  • Postdoc 1989–1991, USDA, New Orleans, Lousiana
Current Research Projects
  • Mycotoxin reduction.
  • Virulence factors aspergillosis.
  • Virulence factors Aspergillus and Fusarium plant pathogens.
  • Anti-microbial discovery: search for novel fungal metabolites with activity towards food contaminating microbes.
Program Affiliations
Outreach / Selected Recent Presentations
  • “Advances in Aspergillus Secondary Metabolite Research: The Good, the Bad, the Beautiful.” Food Research Institute Annual Meeting, May 22, 2012, Madison, WI. 
  • “Ecology of Fungi and Mycotoxins (Pathogens -- Aspergillus Interaction.” Food Research Institute Annual Meeting, May 17, 2011, Madison, WI. 
  • “Antimicrobial Metabolites from Fungi.” Food Research Institute Annual Meeting, May 18, 2010, Madison, WI. 
  • “RNAi Technology to Control Mycotoxin Production.” Food Research Institute Annual Meeting, April 30, 2009, Madison, WI. 

Publications

recent publication Miyamoto K, Murakami T, Kakumyan P, Keller NP, Matsui K. 2014. Formation of 1-octen-3-ol from Aspergillus flavus conidia is accelerated after disruption of cells independently of Ppo oxygenases, and is not a main cause of inhibition of germination. PeerJ 2:e395 (PMC4034645)
recent publication Spraker JE, Jewell K, Roze LV, Scherf J, Ndagano D, Beaudry R, Linz JE, Allen C, Keller NP. 2014. A Volatile Relationship: Profiling an Inter-Kingdom Dialogue Between two Plant Pathogens, Ralstonia Solanacearum and Aspergillus Flavus. J. Chem. Ecol. 40(5):502-13
recent publication Amare MG, Keller NP. 2014. Molecular mechanisms of Aspergillus flavus secondary metabolism and development. Fungal Genet. Biol. 66:11-8
recent publication Knox BP, Deng Q, Rood M, Eickhoff JC, Keller NP, Huttenlocher A. 2014. Distinct Innate Immune Phagocyte Responses to Aspergillus fumigatus Conidia and Hyphae in Zebrafish Larvae. Eukaryotic Cell :
Wiemann P, Keller NP. 2014. Strategies for mining fungal natural products. J. Ind. Microbiol. Biotechnol. 41(2):301-13
Lim FY, Ames B, Walsh CT, Keller NP. 2014. Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus. Cell. Microbiol. :
Keller NP. 2013. Fungal meningitis outbreak editorial. Fungal Genet. Biol. 61:142
Gauthier GM, Keller NP. 2013. Crossover fungal pathogens: the biology and pathogenesis of fungi capable of crossing kingdoms to infect plants and humans. Fungal Genet. Biol. 61:146-57
Wiemann P, Guo CJ, Palmer JM, Sekonyela R, Wang CC, Keller NP. 2013. Prototype of an intertwined secondary-metabolite supercluster. Proc. Natl. Acad. Sci. U.S.A. 110(42):17065-70 (PMC3801025)
Bok JW, Soukup AA, Chadwick E, Chiang YM, Wang CC, Keller NP. 2013. VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation. Mol. Microbiol. 89(5):963-74 (PMC3773851)
Amaike S, Affeldt KJ, Yin WB, Franke S, Choithani A, Keller NP. 2013. The bZIP protein MeaB mediates virulence attributes in Aspergillus flavus. PLoS ONE 8(9):e74030 (PMC3767667)
Tyler BM, Kale SD, Wang Q, Tao K, Clark HR, Drews K, Antignani V, Rumore A, Hayes T, Plett JM, Fudal I, Gu B, Chen Q, Affeldt KJ, Berthier E, Fischer GJ, Dou D, Shan W, Keller NP, Martin F, Rouxel T, Lawrence CB. 2013. Microbe-independent entry of oomycete RxLR effectors and fungal RxLR-like effectors into plant and animal cells is specific and reproducible. Mol. Plant Microbe Interact. 26(6):611-6 (PMC3994703)
Casavant BP, Berthier E, Theberge AB, Berthier J, Montanez-Sauri SI, Bischel LL, Brakke K, Hedman CJ, Bushman W, Keller NP, Beebe DJ. 2013. Suspended microfluidics. Proc. Natl. Acad. Sci. U.S.A. 110(25):10111-6 (PMC3690848)
Patananan AN, Palmer JM, Garvey GS, Keller NP, Clarke SG. 2013. A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine. J. Biol. Chem. 288(20):14032-45 (PMC3656261)
Sekonyela R, Palmer JM, Bok JW, Jain S, Berthier E, Forseth R, Schroeder F, Keller NP. 2013. RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis. PLoS ONE 8(5):e62591 (PMC3646020)
Palmer JM, Bok JW, Lee S, Dagenais TR, Andes DR, Kontoyiannis DP, Keller NP. 2013. Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus. PeerJ 1:e4 (PMC3629006)
Berthier E, Lim FY, Deng Q, Guo CJ, Kontoyiannis DP, Wang CC, Rindy J, Beebe DJ, Huttenlocher A, Keller NP. 2013. Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog. 9(4):e1003289 (PMC3623715)
Karimi-Aghcheh R, Bok JW, Phatale PA, Smith KM, Baker SE, Lichius A, Omann M, Zeilinger S, Seiboth B, Rhee C, Keller NP, Freitag M, Kubicek CP. 2013. Functional analyses of Trichoderma reesei LAE1 reveal conserved and contrasting roles of this regulator. G3 (Bethesda) 3(2):369-78 (PMC3564997)
Yin WB, Baccile JA, Bok JW, Chen Y, Keller NP, Schroeder FC. 2013. A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus. J. Am. Chem. Soc. 135(6):2064-7 (PMC3590312)
Berthier E, Guckenberger DJ, Cavnar P, Huttenlocher A, Keller NP, Beebe DJ. 2013. Kit-On-A-Lid-Assays for accessible self-contained cell assays. Lab Chip 13(3):424-31 (PMC3562598)
Yin WB, Reinke AW, Szilágyi M, Emri T, Chiang YM, Keating AE, Pócsi I, Wang CC, Keller NP. 2013. bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology (Reading, Engl.) 159(Pt 1):77-88 (PMC3542729)
Forseth RR, Amaike S, Schwenk D, Affeldt KJ, Hoffmeister D, Schroeder FC, Keller NP. 2013. Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus. Angew. Chem. Int. Ed. Engl. 52(5):1590-4 (PMC3758896)
Palmer JM, Theisen JM, Duran RM, Grayburn WS, Calvo AM, Keller NP. 2013. Secondary metabolism and development is mediated by LlmF control of VeA subcellular localization in Aspergillus nidulans. PLoS Genet. 9(1):e1003193 (PMC3547832)
Soukup AA, Farnoodian M, Berthier E, Keller NP. 2012. NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion. Fungal Genet. Biol. 49(11):857-65 (PMC3483426)
Soukup AA, Chiang YM, Bok JW, Reyes-Dominguez Y, Oakley BR, Wang CC, Strauss J, Keller NP. 2012. Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production. Mol. Microbiol. 86(2):314-30 (PMC3514908)
Lim FY, Sanchez JF, Wang CC, Keller NP. 2012. Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi. Meth. Enzymol. 517:303-24 (PMC3703436)
Wang S, Cao J, Liu X, Hu H, Shi J, Zhang S, Keller NP, Lu L. 2012. Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans. PLoS ONE 7(10):e46564 (PMC3470553)
Bok JW, Keller NP. 2012. Fast and easy method for construction of plasmid vectors using modified quick-change mutagenesis. Methods Mol. Biol. 944:163-74 (PMC3692276)
Affeldt KJ, Brodhagen M, Keller NP. 2012. Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors. Toxins (Basel) 4(9):695-717 (PMC3475224)
Lim FY, Hou Y, Chen Y, Oh JH, Lee I, Bugni TS, Keller NP. 2012. Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Appl. Environ. Microbiol. 78(12):4117-25 (PMC3370519)
Sanchez JF, Somoza AD, Keller NP, Wang CC. 2012. Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep 29(3):351-71
Yin WB, Amaike S, Wohlbach DJ, Gasch AP, Chiang YM, Wang CC, Bok JW, Rohlfs M, Keller NP. 2012. An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Mol. Microbiol. 83(5):1024-34 (PMC3288630)
Scherm B, Orrù M, Balmas V, Spanu F, Azara E, Delogu G, Hammond TM, Keller NP, Migheli Q. 2011. Altered trichothecene biosynthesis in TRI6-silenced transformants of Fusarium culmorum influences the severity of crown and foot rot on durum wheat seedlings. Mol. Plant Pathol. 12(8):759-71
Amaike S, Keller NP. 2011. Aspergillus flavus. Annu Rev Phytopathol 49:107-33
Forseth RR, Fox EM, Chung D, Howlett BJ, Keller NP, Schroeder FC. 2011. Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis. J. Am. Chem. Soc. 133(25):9678-81 (PMC3151163)
Giles SS, Soukup AA, Lauer C, Shaaban M, Lin A, Oakley BR, Wang CC, Keller NP. 2011. Cryptic Aspergillus nidulans antimicrobials. Appl. Environ. Microbiol. 77(11):3669-75 (PMC3127626)
Yin W, Keller NP. 2011. Transcriptional regulatory elements in fungal secondary metabolism. J. Microbiol. 49(3):329-39
Keller NP, Bennett J, Turner G. 2011. Secondary metabolism: then, now and tomorrow. Fungal Genet. Biol. 48(1):1-3
Shaaban MI, Bok JW, Lauer C, Keller NP. 2010. Suppressor mutagenesis identifies a velvet complex remediator of Aspergillus nidulans secondary metabolism. Eukaryotic Cell 9(12):1816-24 (PMC3008278)
Palmer JM, Mallaredy S, Perry DW, Sanchez JF, Theisen JM, Szewczyk E, Oakley BR, Wang CC, Keller NP, Mirabito PM. 2010. Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans. Microbiology (Reading, Engl.) 156(Pt 12):3522-31 (PMC3068700)
Palmer JM, Keller NP. 2010. Secondary metabolism in fungi: does chromosomal location matter? Curr. Opin. Microbiol. 13(4):431-6 (PMC2922032)
Wiemann P, Brown DW, Kleigrewe K, Bok JW, Keller NP, Humpf HU, Tudzynski B. 2010. FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence. Mol. Microbiol. 77(4):972-94 (PMC2989987)
Shaaban M, Palmer JM, El-Naggar WA, El-Sokkary MA, Habib el-SE, Keller NP. 2010. Involvement of transposon-like elements in penicillin gene cluster regulation. Fungal Genet. Biol. 47(5):423-32 (PMC2863007)
Chiang YM, Oakley BR, Keller NP, Wang CC. 2010. Unraveling polyketide synthesis in members of the genus Aspergillus. Appl. Microbiol. Biotechnol. 86(6):1719-36 (PMC3110678)
Chiang YM, Szewczyk E, Davidson AD, Entwistle R, Keller NP, Wang CC, Oakley BR. 2010. Characterization of the Aspergillus nidulans monodictyphenone gene cluster. Appl. Environ. Microbiol. 76(7):2067-74 (PMC2849234)
Georgianna DR, Fedorova ND, Burroughs JL, Dolezal AL, Bok JW, Horowitz-Brown S, Woloshuk CP, Yu J, Keller NP, Payne GA. 2010. Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters. Mol. Plant Pathol. 11(2):213-26
Dagenais TR, Giles SS, Aimanianda V, Latgé JP, Hull CM, Keller NP. 2010. Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer. Infect. Immun. 78(2):823-9 (PMC2812189)
Chiang YM, Lee KH, Sanchez JF, Keller NP, Wang CC. 2009. Unlocking fungal cryptic natural products. Nat Prod Commun 4(11):1505-10
Lee I, Oh JH, Shwab EK, Dagenais TR, Andes D, Keller NP. 2009. HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production. Fungal Genet. Biol. 46(10):782-90 (PMC2755195)
Giles SS, Dagenais TR, Botts MR, Keller NP, Hull CM. 2009. Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infect. Immun. 77(8):3491-500 (PMC2715683)
Dagenais TR, Keller NP. 2009. Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis. Clin. Microbiol. Rev. 22(3):447-65 (PMC2708386)
Brown SH, Scott JB, Bhaheetharan J, Sharpee WC, Milde L, Wilson RA, Keller NP. 2009. Oxygenase coordination is required for morphological transition and the host-fungus interaction of Aspergillus flavus. Mol. Plant Microbe Interact. 22(7):882-94
Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CC, Keller NP. 2009. Chromatin-level regulation of biosynthetic gene clusters. Nat. Chem. Biol. 5(7):462-4 (PMC2891026)
Amaike S, Keller NP. 2009. Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus. Eukaryotic Cell 8(7):1051-60 (PMC2708460)
Gao X, Brodhagen M, Isakeit T, Brown SH, Göbel C, Betran J, Feussner I, Keller NP, Kolomiets MV. 2009. Inactivation of the lipoxygenase ZmLOX3 increases susceptibility of maize to Aspergillus spp. Mol. Plant Microbe Interact. 22(2):222-31
Bok JW, Keller NP, Tsitsigiannis DI. 2008. Real-time and semiquantitative RT-PCR methods to analyze gene expression patterns during Aspergillus-host interactions. Methods Mol. Biol. 470:151-67
Palmer JM, Perrin RM, Dagenais TR, Keller NP. 2008. H3K9 methylation regulates growth and development in Aspergillus fumigatus. Eukaryotic Cell 7(12):2052-60 (PMC2593193)
Kale SP, Milde L, Trapp MK, Frisvad JC, Keller NP, Bok JW. 2008. Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus. Fungal Genet. Biol. 45(10):1422-9 (PMC2845523)
Horowitz Brown S, Zarnowski R, Sharpee WC, Keller NP. 2008. Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. Appl. Environ. Microbiol. 74(18):5674-85 (PMC2547031)
Dagenais TR, Chung D, Giles SS, Hull CM, Andes D, Keller NP. 2008. Defects in conidiophore development and conidium-macrophage interactions in a dioxygenase mutant of Aspergillus fumigatus. Infect. Immun. 76(7):3214-20 (PMC2446696)
Fox EM, Gardiner DM, Keller NP, Howlett BJ. 2008. A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans. Fungal Genet. Biol. 45(5):671-82 (PMC2399893)
Maggio-Hall LA, Lyne P, Wolff JA, Keller NP. 2008. A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans. Fungal Genet. Biol. 45(3):180-9
Stadler M, Keller NP. 2008. Paradigm shifts in fungal secondary metabolite research. Mycol. Res. 112(Pt 2):127-30
Shwab EK, Keller NP. 2008. Regulation of secondary metabolite production in filamentous ascomycetes. Mycol. Res. 112(Pt 2):225-30
Hammond TM, Bok JW, Andrewski MD, Reyes-Domínguez Y, Scazzocchio C, Keller NP. 2008. RNA silencing gene truncation in the filamentous fungus Aspergillus nidulans. Eukaryotic Cell 7(2):339-49 (PMC2238149)
Hammond TM, Andrewski MD, Roossinck MJ, Keller NP. 2008. Aspergillus mycoviruses are targets and suppressors of RNA silencing. Eukaryotic Cell 7(2):350-7 (PMC2238147)
Brodhagen M, Tsitsigiannis DI, Hornung E, Goebel C, Feussner I, Keller NP. 2008. Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem. Mol. Microbiol. 67(2):378-91
Garscha U, Jernerén F, Chung D, Keller NP, Hamberg M, Oliw EH. 2007. Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism. J. Biol. Chem. 282(48):34707-18
Bouhired S, Weber M, Kempf-Sontag A, Keller NP, Hoffmeister D. 2007. Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet. Biol. 44(11):1134-45
Rohlfs M, Albert M, Keller NP, Kempken F. 2007. Secondary chemicals protect mould from fungivory. Biol. Lett. 3(5):523-5 (PMC2391202)
Shwab EK, Bok JW, Tribus M, Galehr J, Graessle S, Keller NP. 2007. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryotic Cell 6(9):1656-64 (PMC2043372)
Perrin RM, Fedorova ND, Bok JW, Cramer RA, Wortman JR, Kim HS, Nierman WC, Keller NP. 2007. Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA. PLoS Pathog. 3(4):e50 (PMC1851976)
Hoffmeister D, Keller NP. 2007. Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24(2):393-416
Tsitsigiannis DI, Keller NP. 2007. Oxylipins as developmental and host-fungal communication signals. Trends Microbiol. 15(3):109-18
Bok JW, Chung D, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Kirby KA, Keller NP. 2006. GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Infect. Immun. 74(12):6761-8 (PMC1698057)
Bok JW, Noordermeer D, Kale SP, Keller NP. 2006. Secondary metabolic gene cluster silencing in Aspergillus nidulans. Mol. Microbiol. 61(6):1636-45
Tsitsigiannis DI, Keller NP. 2006. Oxylipins act as determinants of natural product biosynthesis and seed colonization in Aspergillus nidulans. Mol. Microbiol. 59(3):882-92
Bok JW, Hoffmeister D, Maggio-Hall LA, Murillo R, Glasner JD, Keller NP. 2006. Genomic mining for Aspergillus natural products. Chem. Biol. 13(1):31-7
Keller NP, Turner G, Bennett JW. 2005. Fungal secondary metabolism - from biochemistry to genomics. Nat. Rev. Microbiol. 3(12):937-47
Tsitsigiannis DI, Kunze S, Willis DK, Feussner I, Keller NP. 2005. Aspergillus infection inhibits the expression of peanut 13S-HPODE-forming seed lipoxygenases. Mol. Plant Microbe Interact. 18(10):1081-9
Bok JW, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Keller NP. 2005. LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryotic Cell 4(9):1574-82 (PMC1214197)
Maggio-Hall LA, Wilson RA, Keller NP. 2005. Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta. Mol. Plant Microbe Interact. 18(8):783-93
Tsitsigiannis DI, Bok JW, Andes D, Nielsen KF, Frisvad JC, Keller NP. 2005. Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect. Immun. 73(8):4548-59 (PMC1201276)
McDonald T, Brown D, Keller NP, Hammond TM. 2005. RNA silencing of mycotoxin production in Aspergillus and Fusarium species. Mol. Plant Microbe Interact. 18(6):539-45
Tsitsigiannis DI, Kowieski TM, Zarnowski R, Keller NP. 2005. Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans. Microbiology (Reading, Engl.) 151(Pt 6):1809-21
Hammond TM, Keller NP. 2005. RNA silencing in Aspergillus nidulans is independent of RNA-dependent RNA polymerases. Genetics 169(2):607-17 (PMC1449118)
Tsitsigiannis DI, Kowieski TM, Zarnowski R, Keller NP. 2004. Endogenous lipogenic regulators of spore balance in Aspergillus nidulans. Eukaryotic Cell 3(6):1398-411 (PMC539017)
Maggio-Hall LA, Keller NP. 2004. Mitochondrial beta-oxidation in Aspergillus nidulans. Mol. Microbiol. 54(5):1173-85
Chang PK, Wilson RA, Keller NP, Cleveland TE. 2004. Deletion of the Delta12-oleic acid desaturase gene of a nonaflatoxigenic Aspergillus parasiticus field isolate affects conidiation and sclerotial development. J. Appl. Microbiol. 97(6):1178-84
Zhang YQ, Brock M, Keller NP. 2004. Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. Genetics 168(2):785-94 (PMC1448837)
Wilson RA, Calvo AM, Chang PK, Keller NP. 2004. Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction. Microbiology (Reading, Engl.) 150(Pt 9):2881-8
Roze LV, Beaudry RM, Keller NP, Linz JE. 2004. Regulation of aflatoxin synthesis by FadA/cAMP/protein kinase A signaling in Aspergillus parasiticus. Mycopathologia 158(2):219-32
Calvo AM, Bok J, Brooks W, Keller NP. 2004. veA is required for toxin and sclerotial production in Aspergillus parasiticus. Appl. Environ. Microbiol. 70(8):4733-9 (PMC492383)
Wilson RA, Chang PK, Dobrzyn A, Ntambi JM, Zarnowski R, Keller NP. 2004. Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development. Fungal Genet. Biol. 41(5):501-9
Bok JW, Keller NP. 2004. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryotic Cell 3(2):527-35 (PMC387652)
Zhang YQ, Keller NP. 2004. Blockage of methylcitrate cycle inhibits polyketide production in Aspergillus nidulans. Mol. Microbiol. 52(2):541-50
Tsitsigiannis DI, Zarnowski R, Keller NP. 2004. The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans. J. Biol. Chem. 279(12):11344-53
Shimizu K, Hicks JK, Huang TP, Keller NP. 2003. Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans. Genetics 165(3):1095-104 (PMC1462812)
Jin Y, Bok JW, Guzman-de-Peña D, Keller NP. 2002. Requirement of spermidine for developmental transitions in Aspergillus nidulans. Mol. Microbiol. 46(3):801-12
Calvo AM, Wilson RA, Bok JW, Keller NP. 2002. Relationship between secondary metabolism and fungal development. Microbiol. Mol. Biol. Rev. 66(3):447-59, table of con (PMC120793)
Wilson RA, Gardner HW, Keller NP. 2001. Cultivar-dependent expression of a maize lipoxygenase responsive to seed infesting fungi. Mol. Plant Microbe Interact. 14(8):980-7
Calvo AM, Gardner HW, Keller NP. 2001. Genetic connection between fatty acid metabolism and sporulation in Aspergillus nidulans. J. Biol. Chem. 276(28):25766-74
Shimizu K, Keller NP. 2001. Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157(2):591-600 (PMC1461531)
Hodges RL, Kelkar HS, Xuei X, Skatrud PL, Keller NP, Adams TH, Kaiser RE, Vinci VA, McGilvray D. 2000. Characterization of an echinocandin B-producing strain blocked for sterigmatocystin biosynthesis reveals a translocation in the stcW gene of the aflatoxin biosynthetic pathway. J. Ind. Microbiol. Biotechnol. 25(6):333-341
Burow GB, Gardner HW, Keller NP. 2000. A peanut seed lipoxygenase responsive to Aspergillus colonization. Plant Mol. Biol. 42(5):689-701
Keller NP, Watanabe CM, Kelkar HS, Adams TH, Townsend CA. 2000. Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Appl. Environ. Microbiol. 66(1):359-62 (PMC91830)
Butchko RA, Adams TH, Keller NP. 1999. Aspergillus nidulans mutants defective in stc gene cluster regulation. Genetics 153(2):715-20 (PMC1460771)
Calvo AM, Hinze LL, Gardner HW, Keller NP. 1999. Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. Appl. Environ. Microbiol. 65(8):3668-73 (PMC91549)
Fernandes M, Keller NP, Adams TH. 1998. Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Mol. Microbiol. 28(6):1355-65
Keller NP, Nesbitt C, Sarr B, Phillips TD, Burow GB. 1997. pH Regulation of Sterigmatocystin and Aflatoxin Biosynthesis in Aspergillus spp. Phytopathology 87(6):643-8
Keller NP, Hohn TM. 1997. Metabolic Pathway Gene Clusters in Filamentous Fungi Fungal Genet. Biol. 21(1):17-29
Keller NP, Hohn TM. 1997. Metabolic pathway gene clusters in filamentous fungi. Fungal Genet. Biol. 21(1):17-29
Kelkar HS, Skloss TW, Haw JF, Keller NP, Adams TH. 1997. Aspergillus nidulans stcL encodes a putative cytochrome P-450 monooxygenase required for bisfuran desaturation during aflatoxin/sterigmatocystin biosynthesis. J. Biol. Chem. 272(3):1589-94
Brown DW, Adams TH, Keller NP. 1996. Aspergillus has distinct fatty acid synthases for primary and secondary metabolism. Proc. Natl. Acad. Sci. U.S.A. 93(25):14873-7 (PMC26229)
Kelkar HS, Keller NP, Adams TH. 1996. Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis. Appl. Environ. Microbiol. 62(11):4296-8 (PMC168255)
Keller NP, Adams TH. 1995. Analysis of a mycotoxin gene cluster in Aspergillus nidulans. SAAS Bull. Biochem. Biotechnol. 8:14-21
Keller NP, Segner S, Bhatnagar D, Adams TH. 1995. stcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans. Appl. Environ. Microbiol. 61(10):3628-32 (PMC167660)
Keller NP, Kantz NJ, Adams TH. 1994. Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin. Appl. Environ. Microbiol. 60(5):1444-50 (PMC201501)
Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller NP, Chu FS. 1993. Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. Appl. Environ. Microbiol. 59(11):3564-71 (PMC182499)
Keller NP, Dischinger HC, Bhatnagar D, Cleveland TE, Ullah AH. 1993. Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway. Appl. Environ. Microbiol. 59(2):479-84 (PMC202130)