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UW-Madison Food Research Institute
Pictures of MWP Michael W. Pariza

Core Executive Committee, Food Research Institute
Professor Emeritus, Department of Food Science, UW-Madison

3203 Microbial Sciences Building
1550 Linden Drive
(608) 263-6955
mwpariza@wisc.edu

Research Interests
Dietary aspects of carcinogenesis; Biological significance of conjugated linoleic acid (CLA) and other naturally occurring biological compounds in food
Department Webpage
http://foodsci.wisc.edu/faculty/pariza/
Education
  • BS 1967, Bacteriology, University of Wisconsin–Madison
  • MS 1969, Microbiology, Kansas State University
  • PhD 1973, Microbiology, Kansas State University
  • Postdoc, McArdle Laboratory for Cancer Research, University of Wisconsin–Madison

Publications

Lahlou MN, Kanneganti R, Massingill LJ, Broderick GA, Park Y, Pariza MW, Ferguson JD, Wu Z. 2014. Grazing increases the concentration of CLA in dairy cow milka. Animal :1-10
Walker J, Rohm B, Lang R, Pariza MW, Hofmann T, Somoza V. 2011. Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12). Food Chem. Toxicol. 50(2):390-8
Pariza MW, Cook M. 2010. Determining the safety of enzymes used in animal feed. Regul. Toxicol. Pharmacol. 56(3):332-42
Li G, Dong B, Butz DE, Park Y, Pariza MW, Cook ME. 2006. NF-kappaB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid. Biochim. Biophys. Acta 1761(9):969-72
Li G, Butz D, Dong B, Park Y, Pariza MW, Cook ME. 2006. Selective conjugated fatty acids inhibit guinea pig platelet aggregation. Eur. J. Pharmacol. 545(2-3):93-9
Park Y, Yang H, Storkson JM, Albright KJ, Liu W, Lindsay RC, Pariza MW. 2006. Controlling acrylamide in French fry and potato chip models and a mathematical model of acrylamide formation: acrylamide: acidulants, phytate and calcium. Adv. Exp. Med. Biol. 561:343-56
Park Y, Storkson JM, Liu W, Albright KJ, Cook ME, Pariza MW. 2004. Structure-activity relationship of conjugated linoleic acid and its cognates in inhibiting heparin-releasable lipoprotein lipase and glycerol release from fully differentiated 3T3-L1 adipocytes. J. Nutr. Biochem. 15(9):561-8
Pariza MW. 2004. Perspective on the safety and effectiveness of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6 Sup):1132S-1136S
Kang K, Miyazaki M, Ntambi JM, Pariza MW. 2004. Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. Biochem. Biophys. Res. Commun. 315(3):532-7
Kang K, Liu W, Albright KJ, Park Y, Pariza MW. 2003. trans-10,cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPAR gamma expression. Biochem. Biophys. Res. Commun. 303(3):795-9
Xu X, Storkson J, Kim S, Sugimoto K, Park Y, Pariza MW. 2003. Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue. J. Nutr. 133(3):663-7
Ntambi JM, Choi Y, Park Y, Peters JM, Pariza MW. 2002. Effects of conjugated linoleic acid (CLA) on immune responses, body composition and stearoyl-CoA desaturase. Can J Appl Physiol 27(6):617-28
Pariza MW. 2002. Conjugated linoleic acid may be useful in treating diabetes by controlling body fat and weight gain. Diabetes Technol. Ther. 4(3):335-8
Choi Y, Park Y, Storkson JM, Pariza MW, Ntambi JM. 2002. Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells. Biochem. Biophys. Res. Commun. 294(4):785-90
Whigham LD, Higbee A, Bjorling DE, Park Y, Pariza MW, Cook ME. 2002. Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282(4):R1104-12
Doyle ME, Pariza MW. 2001. Foodborne microbial pathogens and the food research institute. Adv. Appl. Microbiol. 49:143-61
Park Y, Pariza MW. 2001. Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. Biochim. Biophys. Acta 1534(1):27-33
Park Y, Pariza MW. 2001. The effects of dietary conjugated nonadecadienoic acid on body composition in mice. Biochim. Biophys. Acta 1533(3):171-4
Kang K, Pariza MW. 2001. trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 287(2):377-82
Pariza MW, Park Y, Cook ME. 2001. The biologically active isomers of conjugated linoleic acid. Prog. Lipid Res. 40(4):283-98
Choi Y, Park Y, Pariza MW, Ntambi JM. 2001. Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid in HepG2 cells. Biochem. Biophys. Res. Commun. 284(3):689-93
Pariza MW, Johnson EA. 2001. Evaluating the safety of microbial enzyme preparations used in food processing: update for a new century. Regul. Toxicol. Pharmacol. 33(2):173-86
Park Y, Albright KJ, Cai ZY, Pariza MW. 2001. Comparison of methylation procedures for conjugated linoleic acid and artifact formation by commercial (trimethylsilyl) diazomethane. J. Agric. Food Chem. 49(3):1158-64
Aydin R, Pariza MW, Cook ME. 2001. Olive oil prevents the adverse effects of dietary conjugated linoleic acid on chick hatchability and egg quality. J. Nutr. 131(3):800-6
Whigham LD, Cook EB, Stahl JL, Saban R, Bjorling DE, Pariza MW, Cook ME. 2001. CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280(3):R908-12
Yang M, Pariza MW, Cook ME. 2000. Dietary conjugated linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouse. Immunopharmacol Immunotoxicol 22(3):433-49
Choi Y, Kim YC, Han YB, Park Y, Pariza MW, Ntambi JM. 2000. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J. Nutr. 130(8):1920-4
Park Y, Storkson JM, Ntambi JM, Cook ME, Sih CJ, Pariza MW. 2000. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta 1486(2-3):285-92
Pariza MW, Park Y, Cook ME. 2000. Mechanisms of action of conjugated linoleic acid: evidence and speculation. Proc. Soc. Exp. Biol. Med. 223(1):8-13
Pariza MW, Park Y, Cook ME. 1999. Conjugated linoleic acid and the control of cancer and obesity. Toxicol. Sci. 52(2 Sup):107-10
Dhiman TR, Anand GR, Satter LD, Pariza MW. 1999. Conjugated linoleic acid content of milk from cows fed different diets. J. Dairy Sci. 82(10):2146-56
Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. 1999. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34(3):243-8
Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. 1999. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34(3):235-41
Park Y, Pariza MW. 1998. Evidence that commercial calf and horse sera can contain substantial amounts of trans-10,cis-12 conjugated linoleic acid. Lipids 33(8):817-9
Lee KN, Pariza MW, Ntambi JM. 1998. Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. Biochem. Biophys. Res. Commun. 248(3):817-21
Pariza MW. 1997. Animal studies: summary, gaps, and future research. Am. J. Clin. Nutr. 66(6 Sup):1539S-1540S
Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. 1997. Effect of conjugated linoleic acid on body composition in mice. Lipids 32(8):853-8
Lee KN, Pariza MW, Ntambi JM. 1996. Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice. Biochim. Biophys. Acta 1304(2):85-8
Chin SF, Storkson JM, Albright KJ, Cook ME, Pariza MW. 1994. Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J. Nutr. 124(12):2344-9
Lee KN, Kritchevsky D, Pariza MW. 1994. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108(1):19-25
Chin SF, Storkson JM, Liu W, Albright KJ, Pariza MW. 1994. Conjugated linoleic acid (9,11- and 10,12-octadecadienoic acid) is produced in conventional but not germ-free rats fed linoleic acid. J. Nutr. 124(5):694-701
Pariza MW. 1992. Designer foods: effects on development of cancer. J. Natl. Cancer Inst. Monographs (12):105-7
Pariza MW. 1992. Risk assessment. Crit Rev Food Sci Nutr 31(3):205-9
Nagahara A, Benjamin H, Storkson J, Krewson J, Sheng K, Liu W, Pariza MW. 1992. Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia by a principal flavor component of Japanese-style fermented soy sauce. Cancer Res. 52(7):1754-6
Pariza MW. 1992. A new approach to evaluating carcinogenic risk. Proc. Natl. Acad. Sci. U.S.A. 89(3):860-1 (PMC48341)
Pariza MW, Ha YL, Benjamin H, Sword JT, Grüter A, Chin SF, Storkson J, Faith N, Albright K. 1991. Formation and action of anticarcinogenic fatty acids. Adv. Exp. Med. Biol. 289:269-72
Benjamin H, Storkson J, Nagahara A, Pariza MW. 1991. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by dietary soy sauce. Cancer Res. 51(11):2940-2
Pariza MW, Ha YL. 1990. Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. Med Oncol Tumor Pharmacother 7(2-3):169-71
Pariza MW, Ha YL. 1990. Conjugated dienoic derivatives of linoleic acid: mechanism of anticarcinogenic effect. Prog. Clin. Biol. Res. 347:217-21
Pariza MW, Ha YL. 1990. Newly recognized anticarcinogenic fatty acids. Basic Life Sci. 52:167-70
Ha YL, Storkson J, Pariza MW. 1990. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res. 50(4):1097-101
Pariza MW. 1989. Dietary fat and cancer risk: evidence and research needs. Annu. Rev. Nutr. 8:167-83
Benjamin H, Storkson J, Tallas PG, Pariza MW. 1988. Reduction of benzo[a]pyrene-induced forestomach neoplasms in mice given nitrite and dietary soy sauce. Food Chem. Toxicol. 26(8):671-8
Ha YL, Grimm NK, Pariza MW. 1987. Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis 8(12):1881-7