Laura J. Knoll
Core Executive Committee, Food Research Institute
3303 Microbial Sciences Building
Molecular parasitology; Vaccine development for the intracellular parasite Toxoplasma gondii
- B.A. - 1989; Saint Olaf College; Northfield, MN
- Ph.D. - 1994; Washington University School of Medicine; St. Louis, MO
- Postdoctoral Research- Stanford University; Stanford, CA
A primary area of research in the Knoll laboratory centers on studying the host/pathogen interactions of the intracelluar parasite Toxoplasma gondii. Toxoplasma causes abnormal fetal neurological development and encephalitis in immunocompromised patients. Toxoplasma is a member of the coccidian family of parasites that include Plasmodium (causative agent of malaria) and Cryptosporidium (causative agent of water-borne outbreaks of diarrhea). We are using a library signature-tagged mutants and a chronic infection mouse model to isolate genes important for virulence and developmental regulation.
- Combining Next Generation Sequencing with molecular genetics to create a toxoplasma vaccine.
- Genome-Wide siRNA Screen to Identify Host Factors Necessary for Growth of the Parasite Toxoplasma gondii.
- Toxoplasma gondii mutant highlights the importance of translational regulation in the apicoplast during animal infection.
- “Foodborne Parasitic Risks and Infections.” Food Research Institute Annual Meeting, May 22, 2014, Madison, WI.
- “Combining Next Generation Sequencing with Molecular Genetics to Create a Toxoplasma Vaccine.” Food Research Institute Annual Meeting, May 22, 2013, Madison, WI.
- “Development of a Non-persistent Toxoplasma Vaccine and Broad-spectrum Immunotherapeutics.” Food Research Institute Annual Meeting, May 22, 2012, Madison, WI.
- “Understanding the Connection Between the Human Microbiota, Metabolism, and Obesity.” Food Research Institute Annual Meeting, May 18, 2010, Madison, WI.
- “Creation of an Animal Vaccine for Foodborne Parasites.” Food Research Institute Annual Meeting, April 30, 2009 , Madison, WI.